What is Combination Therapy?
How does combination therapy work?
There are two types of medications that are approved to treat the symptoms of Alzheimer's disease:
NMDA-receptor antagonist & acetylcholinesterase inhibitors
NAMENDA is the only glutamate pathway modifier, and it works differently than the acetylcholinesterase inhibitors. Glutamate is a chemical in the brain that is important for learning and memory. NAMENDA works by regulating the activity of glutamate in the brain in order to help memory and learning.
ARICEPT, EXELON** (rivastigmine tartrate), and RAZADYNE*** (galantamine HBr) are acetylcholinesterase inhibitors—another class of drugs approved to treat the symptoms of Alzheimer's disease. They work by helping to increase the amount of acetylcholine in the brain—a chemical that is important for memory and learning. They are approved to treat the symptoms of mild to moderate Alzheimer's disease. ARICEPT is also approved to treat the symptoms of severe Alzheimer's disease.
NAMENDA and ARICEPT 5-10 mg work in different ways; taking them together may be beneficial.
There is no evidence that NAMENDA or donepezil prevents or slows the underlying disease process in patients with Alzheimer’s disease.